Dr Alex Best - Infectious Disease Dynamics Group

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Singh, P. and Best, A. (2021) Simultaneous evolution of host resistance and tolerance to parasitism. J. Evol. Biol., In Press

Ward, C. and Best, A. (2021). How seasonal variations in birth and transmission rates impact population dynamics in an epidemiological model. Ecol. Complexity, In Press

Best, A., Singh, P.., Ward, C., Vitale, C., Oliver, M., Idris, L. and Poulston, A. (2021). The impact of varying class sizes on epidemic spread in a university population. Roy. Soc. Open Science, 8:210712.

Best, A. and Ashby, B. (2021). Evolutionarily stable strategies are well studied in periodically fluctuating populations. Proc. Nat. Acad. Sci., 118:e2102001118

Ashby, B. and Best, A. (2021). Herd Immunity. Curr. Biol., 31:R1-R5.

Ferris, C., Wright, R., Brockhurst, M. and Best, A. (2020). The evolution of host resistance and parasite infectivity is highest in seasonal resource environments that oscillate at intermediate amplitudes. Proc. Roy, Soc. B. 287:20200787.

Best, A., Jubrail, J., Boots, M., Dockerell, D. and Marriott, H. (2020). A mathematical model shows that macrophages delay Staphylococcus aureus replication, but limitations in microbicidal capacity restrict the extent of bacterial clearance. J. Theor. Biol. 497:110256.

Ferris, C. and Best, A. (2019). The effect of temporal fluctuations on the evolution of host tolerance to parasitism. Theor. Pop. Biol., In Press.

Vitale, C. and Best, A. (2019). The impact of selective predation on host-parasite SIS dynamics. Bull. Math. Biol., In Press.

Vitale, C. and Best, A. (2019). The paradox of tolerance: Parasite extinction due to the evolution of host defence. J. Theor. Biol. 474:78-87.

Ashby, B., Iritani, R. Best, A. and Boots, M. (2018). Understanding the role of eco-evolutionary feedbacks in host-parasite coevolution. J. Theor. Biol. 464:115-125.

Best, A. (2018). Host-pathogen coevolution in the presence of predators: fluctuating selection and ecological feedbacks. Proc. R. Soc. B., 285:20180928.

Boots, M. and Best, A. (2018). The evolution of constitutive vs induced defense to infectious disease. Proc. R. Soc. B., 285:20180658.

Ferris, C. and Best, A. (2018). The evolution of host defence to parasitism in fluctuating environments. J. Theor. Biol., 440:58-65.

Best, A., Ashby, B., White, A., Bowers, R., Buckling, A., Koskella, B and Boots, M. (2017). Host-parasite fluctuating selection in the absence of specificity. Proc. R. Soc. B., 284:20171615.

Best, A., White, A. and Boots, M. (2017). The evolution of host defence when parasites impact reproduction. Evol. Ecol. Res., 18.

Toor, J. and Best, A. (2016). The evolution of host defence against two enemies. Am. Nat., 187:308-319.

Hesse, E., Best, A., Boots, M., Hall, A. and Buckling, A. (2015). Spatial heterogeneity lowers rather than increases diversity by reducing host-parasite specialisation. J. Evol. Biol., 28:1682-1690.

Best A., Bowers, R, and White, A. (2015). Evolution, the loss of diversity and the role of trade-offs. Math. Biosci., 264:86-93.

Westra, E., van Houte, S., Oyesiku-Blakemore, S., Makin, B., Broniewski, J. Best, A., Bondy-Deonmy, J., Davidson, A., Boots, M. and Buckling, A. (2015). Parasite exposure drives selective evolution of constitutive versus inducible defense. Curr. Biol., 25:1043-1049.

Toor, J. and Best A. (2015). The evolution of host resistance to disease in the presence of predators. J. Theor. Biol., 365:104-111.

Lopez-Pascua, L., Hall, A. R., Best, A., Morgan, A. D., Boots, M. and Buckling, A. (2014). Higher resources decrease fluctuating selection during host-parasite coevolution. Ecology Letters.

Boots, M., White, A, Best, A. and Bowers, R. (2014). How specificity and epidemiology drive the coevolution of static trait diversity in hosts and parasites. Evolution, 68:1594-1606

Best A., White, A, and Boots, M. (2014). The coevolutionary implications of host tolerance. Evolution. 68:1426-1435

Best A. and Hoyle, A. (2013). A limited host immune range facilitates the creation and maintenance of diversity in parasite virulence. Interface Focus, 3:20130024

Best A. (2013). The effects of seasonal forcing on invertebrate-disease interactions with immune priming. Bull. Math. Biol. 75:2241-2256.

Best A. and Hoyle, A. (2013). The evolution of costly acquired immunity. Ecol. Evol., 3:2223-2232.

Best, A., Tidbury, H., White, A. and Boots, M. (2013). The evolutionary dynamics of within-generation immune priming in invertebrate hosts.J. Roy. Soc. Interface, 10:20120887

Donnelly, R., Best, A., White, A. and Boots, M. (2012). Seasonality selects for more acutely virulent parasites when virulence is density dependent.Proc. Roy. Soc. B, 280:20122464

Hoyle, A., Best A. and Bowers, R. (2012). The evolution of host resistance towards pathogen exclusion: the role of predators.Evol. Ecol. Res., 14:125-146

Morozov, A. and Best A. (2012). Predation on infected hosts promotes evolutionary branching of virulence and pathogen biodiversity.J. Theor. Biol., 307:29-36

Boots, M., White, A., Best, A., and Bowers, R. (2012). Diversity in host resistance: the importance of who infects whom.Ecol. Lett., 15:1104-1111

Tidbury, H., Best, A. and Boots, M. (2012). The epidemiological consequences of immune priming.Proc. Roy. Soc. B, 279:4505-4512

Best A., Long, G., White, A. and Boots, M. (2012). The implications of immunopathology for parasite evolution.Proc. Roy. Soc. B, 279:3234-3240

Best, A., Webb, S., Antonovics, J. and Boots, M. (2012). The implications of local frequency- and density-dependent transmission to infectious disease dynamics and host extinctions.Theor. Ecol.,5:211-217

Best, A., Webb, S., White, A. and Boots, M. (2011). Host resistance and coevolution in spatially structured populations.Proc. Roy. Soc. B, 278:2216-2222. PDF

Vale, P., Best, A., Wilson, A., Boots, M. and Little, T. (2011). Epidemiological, evolutionary and coevolutionary implications of context-dependent parasitism.Am. Nat. , 177:510-521. PDF

Best, A., White, A., Kisdi, E., Antonovics, J., Brockhurst, M. and Boots, M. (2010). The evolution of host-parasite range.Am. Nat., 176:63-71 PDF

Best, A., White, A. and Boots, M. (2010). Resistance is futile but tolerance can explain why parasites do not always castrate their hosts.Evolution, 64:348-357. PDF

Best, A., White, A. and Boots, M. (2009). The implications of coevolutionary dynamics to host-parasite interactions. Am. Nat., 173:779-791 PDF

Boots, M., Best, A., Miller, M. and White, A. (2009). The role of ecological feedbacks in the evolution of host defence: what does theory tell us? Phil. Trans. R. Soc. B, 364:27-36 PDF

Best, A., White, A. and Boots, M. (2008). The maintenance of host variation in tolerance to pathogens and parasites. Proc. Natl. Acad. Sci., 105:20786-20791. PDF

Travis, J., M端nkem端ller, T., Burton, O., Best, A., Dytham, C. and Johst, K. (2007). Deleterious mutations can surf to high densities on the wave front of an expanding population.Mol. Biol. Evol., 24:2334-2343. PDF

Best, A., Johst, K., M端nkem端ller, T. and Travis, J. (2007). Which species will successfully track climate change? The influence of intraspecific competition and density dependent dispersal on range shifting dynamics.Oikos, 116:1531-1539. PDF